To disable Microsoft Edge first run you have to jump through a few hoops. Luckily i've done this for you.
Many blogs state that you just need to change the value of "IE10TourShown" in the following:
However this is not enough. To fix edge you need to set these values.
I deploy these values by Group Policy Preferences.
Open your relevant workstation policy and navigate to :User Configuration>Preferences>Windows Settings>Registry
From here add a registry items for all settings above from HKEY_CLASSES_ROOT.
Next, create a folder (collection item) and within in add all the items above from HKEY_CURRENT_USER. Once added, right click on your collection folder, navigate the "common" tab, and select "Run in logged-on users security context (user policy option)" .
And thats it, with this set users should not see the "first run" edge wizard. Further configuration of edge can be made from Admin Templates>Windows Components>Microsoft Edge.